AKR1C2 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comAKR1C2 Polyclonal Antibody for Human(Homo sapiens) | EIAab.com

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AKR1C2 (Gene name),

Aldo-keto reductase family 1 member C2 (Protein name ), AK1C2_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

AKR1C2(DDH2);

Protein name:

Aldo-keto reductase family 1 member C2;

Alternative:

Chlordecone reductase homolog HAKRD;3-alpha-HSD3;Dihydrodiol dehydrogenase/bile acid-binding protein(DD/BABP);Dihydrodiol dehydrogenase 2(DD-2;DD2);1.1.1.357;Type III 3-alpha-hydroxysteroid dehydrogenase);1.3.1.20;Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

323

Sequence:

50:

MDSKYQCVKL | NDGHFMPVLG | FGTYAPAEVP | KSKALEAVKL | AIEAGFHHID |

100:

SAHVYNNEEQ | VGLAIRSKIA | DGSVKREDIF | YTSKLWSNSH | RPELVRPALE |

150:

RSLKNLQLDY | VDLYLIHFPV | SVKPGEEVIP | KDENGKILFD | TVDLCATWEA |

200:

MEKCKDAGLA | KSIGVSNFNH | RLLEMILNKP | GLKYKPVCNQ | VECHPYFNQR |

250:

KLLDFCKSKD | IVLVAYSALG | SHREEPWVDP | NSPVLLEDPV | LCALAKKHKR |

300:

TPALIALRYQ | LQRGVVVLAK | SYNEQRIRQN | VQVFEFQLTS | EEMKAIDGLN |

323:

RNVRYLTLDI | FAGPPNYPFS | DEY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

KEGG:

STRING:

9606.ENSP00000370129

KEGG:

UniGene:

SMR:

Pfam:

MIM:

Uniprot:

FOR

ELISA Kit for Human Aldo-keto reductase family 1 member C2

Cat.:

E2111h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Aldo-keto reductase family 1 member C2

Cat.:

U2111h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Aldo-keto reductase family 1 member C2

Cat.:

P2111Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Aldo-keto reductase family 1 member C2

Protein for Human Aldo-keto reductase family 1 member C2

R&D Technical Data

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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References

1.

"Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase."
Qin K.-N. , New M.I. , Cheng K.-C.
J. Steroid Biochem. Mol. Biol.46:673-679(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
2.

"cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase."
Ciaccio P.J. , Tew K.D.
Biochim. Biophys. Acta1186:129-132(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Colon.
3.

"Structure of a gene coding for human dihydrodiol dehydrogenase/bile acid-binding protein."
Qin K.-N. , Khanna M. , Cheng K.-C.
Gene149:357-361(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANT TYR-46
4.

"Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids."
Dufort I. , Soucy P. , Labrie F. , Luu-The V.
Biochem. Biophys. Res. Commun.228:474-479(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
tissue: Prostate.
5.

"Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA."
Shiraishi H. , Ishikura S. , Matsuura K. , Deyashiki Y. , Ninomiya M. , Sakai S. , Hara A.
Biochem. J.334:399-405(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
6.

"Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes."
Nishizawa M. , Nakajima T. , Yasuda K. , Kanzaki H. , Sasaguri Y. , Watanabe K. , Ito S.
Genes Cells5:111-125(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
tissue: Liver.
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Tongue.
8.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
9.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
tissue: Urinary bladder.
11.

"Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells."
Hara A. , Matsuura K. , Tamada Y. , Sato K. , Miyabe Y. , Deyashiki Y. , Ishida N.
Biochem. J.313:373-376(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-31; 40-62; 69-100; 105-131; 137-153; 162-206; 209-231; 250-269 AND 271-323;FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
12.

"cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family."
Stolz A. , Hammond L. , Lou H. , Takikawa H. , Ronk M. , Shively J.E.
J. Biol. Chem.268:10448-10457(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 10-29; 40-55; 76-101; 105-128; 137-146; 162-197; 208-223; 259-270 AND 305-322
tissue: Liver.
13.

"Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation."
Fluck C.E. , Meyer-Boni M. , Pandey A.V. , Kempna P. , Miller W.L. , Schoenle E.J. , Biason-Lauber A.
Am. J. Hum. Genet.89:201-218(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;VARIANTS SRXY8 VAL-79; GLN-90; GLN-222 AND THR-300;CHARACTERIZATION OF VARIANTS SRXY8 VAL-79; GLN-90; GLN-222 AND THR-300
14.

"Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate."
Jin Y. , Stayrook S.E. , Albert R.H. , Palackal N.T. , Penning T.M. , Lewis M.
Biochemistry40:10161-10168(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEX WITH NADP AND URSODEOXYCHOLATE
15.

"Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution."
Nahoum V. , Gangloff A. , Legrand P. , Zhu D.-W. , Cantin L. , Zhorov B.S. , Luu-The V. , Labrie F. , Breton R. , Lin S.X.
J. Biol. Chem.276:42091-42098(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) IN COMPLEX WITH NADP AND TESTOSTERONE
16.

"Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an 'induced-fit' mechanism and a conserved basic motif involved in the binding of androgen."
Couture J.F. , de Jesus-Tran K.P. , Roy A.M. , Cantin L. , Cote P.L. , Legrand P. , Luu-The V. , Labrie F. , Breton R.
Protein Sci.14:1485-1497(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 2-323 IN COMPLEX WITH NADP;FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF ARG-301 AND ARG-304
17.

"Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme."
Faucher F. , Pereira de Jesus-Tran K. , Cantin L. , Luu-The V. , Labrie F. , Breton R.
J. Mol. Biol.364:747-763(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH NADP;FUNCTION;CATALYTIC ACTIVITY
18.

"Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding."
Faucher F. , Cantin L. , Pereira de Jesus-Tran K. , Lemieux M. , Luu-The V. , Labrie F. , Breton R.
J. Mol. Biol.369:525-540(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 3-323 IN COMPLEX WITH NADP AND HYDROXYANDROSTERONE;FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF TYR-24 AND LYS-31

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